Urinary-Pro provides clinical doses of four herbal extracts that support healthy urinary function. A unique combination of bearberry (uva ursi), juniper, echinacea purpurea, and berberine extracts promote antimicrobial and antioxidant activity along the urinary tract, inhibiting bacterial growth and adhesion while supporting immune function.
Bearberry has the highest natural content of the phenol arbutin (hydroquinone beta-D-glucoside) and has long been used as a urinary antiseptic. The hydroquinone aglycone of arbutin, which is released in alkaline urine, is believed to provide its antimicrobial action. In a clinical trial, women with recurrent cystitis had no infections over a one-year period when they consumed bearberry, compared to 23% of the placebo group. Berberine, well known for its antibacterial properties, has been shown to inhibit the adhesion of E. coli to human bladder cells, as well as the formation of bacterial biofilms by E. faecalis, in vitro. Berberine has also been shown to have anti-inflammatory effects and protect against oxidative damage, in part by enhancing the activity of nuclear factor erythroid-related factor 2 (Nrf2), a key signaling pathway for antioxidant defense.
Urinary-Pro also provides a 4:1 extract of juniper, known for its antimicrobial, antioxidant, and diuretic properties, and has been shown to prevent the adhesion and growth of several bacterial species, including E. coli, in vitro. A 6:1 extract of Echinacea purpurea supports healthy urinary function by modulating innate and specific immune activity. In addition, it has been shown to have both antiviral and antibacterial properties.