The microbial ecosystem of the gastrointestinal (GI) tract has become a "virtual organ system," increasingly recognized for its importance in maintaining health and preventing disease. The GI microbiota plays a critical role in maintaining innate and cell-mediated immune system homeostasis and improves intestinal barrier function through several mechanisms, including toxin metabolism, tight junction protein phosphorylation, and inflammation reduction. Research has clearly demonstrated the importance of gut bacteria not only in maintaining optimal gastrointestinal health, but also in chronic and systemic diseases such as type 2 diabetes, obesity, and other inflammatory or autoimmune diseases.
Probiotics exhibit multifactorial benefits, modulating intestinal immune responses and intestinal barrier functions in a strain- and dose-dependent manner. Furthermore, probiotic mixtures appear to be more effective than individual strains, perhaps due to synergistic activity or because individuals respond differently to various strains.
Probiotic-Pro12 contains 12 bacterial species, each chosen for its ability to withstand stomach acid and high bile concentrations, as well as its clinically proven benefits through individual mechanisms of action. High-quality lactic acid bacteria require considerable care at all times, which is why more than 20 rigorous quality control measures are implemented to ensure strain consistency and product quality.