Oxidative damage to mitochondria is a major factor in cellular aging, as well as neurological decline. While lifestyle interventions such as calorie restriction help improve mitochondrial function in young, non-obese adults, certain supplements such as L-carnitine also offer therapeutic benefits. The salt of L-carnitine, called acetyl-L-carnitine (ALC), is the preferred form in cases of disease and aging because it is better absorbed and easily crosses the blood-brain barrier. ALC has been shown not only to improve mood but also to play an important role in disorders of aging, including fatigue, hypertension, insulin resistance, diabetic neuropathy, and dementia.
Mito AMP also contains Ginkgo biloba extract, resveratrol, R-alpha-lipoic acid, and grape seed proanthocyanidins, all of which modulate mitochondrial function, improve cognitive function, and/or reduce inflammation associated with cognitive decline. Pyrroloquinoline quinone (PQQ) plays a key role in mitochondrial biogenesis through cellular signaling (PGC-1 alpha). Clinical trials have shown improved cerebral blood flow and brain function, improved memory when combined with CoQ10, as well as increased vigor and significant reductions in symptoms of fatigue, tension, low mood, and confusion.