Magnesium is available in many different forms, each with its own clinical application. In the case of magnesium orotate, the clinical benefit is seen with systems that have a high energy (ATP) demand, such as the cardiovascular system. The benefit of magnesium orotate is as much the by-product of orotic acid as it is of magnesium. Orotic acid is considered a "magnesium-binding agent" due to its influence on magnesium binding sites. Mg-Orotate 500TM provides 500 mg of fully reacted magnesium orotate, delivering 62.5 mg of elemental magnesium and 437.5 mg of orotic acid per 2-capsule serving.