Melatonin, a naturally occurring indolamine, is produced primarily in the pineal gland, but also in the bone marrow, platelets, gastrointestinal tract, eyes, skin, and lymphocytes of mammals. It plays a critical role in regulating the body's daily and annual biological rhythms, including the sleep-wake cycle. Research suggests that melatonin also supports antioxidant activity, cardiovascular health, and immune function.