HMF Replete supports healthy intestinal microflora throughout antibiotic use and in adults with IBS. The intestines contain over 400 bacterial species, and bacterial balance must be maintained for a healthy gut. Antibiotics alter the intestinal microflora and can lead to the overgrowth of antibiotic-resistant bacteria. Probiotics help maintain a naturally healthy microflora and promote the maintenance of normal intestinal flora after antibiotic therapy. IBS affects nearly 5 million Canadians and can also result from an altered intestinal microflora. This leads to malabsorption of bile acids—which aid in the digestion of fats—and in turn increases the secretion of fluid and mucus in the colon to dilute the bile acids. Because lactobacilli and bifidobacteria help reabsorb bile acids, less water enters the colon, decreasing the occurrence of diarrhea. In a randomized, placebo-controlled trial of 52 adults with IBS, daily supplementation with CUL-60, CUL-21, CUL-20, and CUL-34 significantly improved quality of life and satisfaction with bowel habits, and reduced the number of days with pain within 10 weeks.