Cycle Matrix (Fertility Matrix) Ovulatory & Oocyte Support

• A powdered blend of evidence-based nutrients for optimal hormone regulation, egg development, and fertility support in women. Peach and mango flavor for improved compliance.

  Designed to support female fertility, including ovulation, oocyte quality, embryonic development and successful gestation.

  Inositol and NAC support insulin and hormonal balance in cases of polycystic ovarian syndrome (PCOS), a condition known to predispose to infertility.

  Coenzyme Q10 and PQQ provide mitochondrial support to improve egg quality, embryo implantation, and embryonic growth.

  L-arginine increases blood flow to the pelvic organs and promotes endometrial thickness, endometrial receptivity, and follicular growth.
  

  Folate is provided in the active form of 5-MTHF to improve oocyte development, embryo quality and live birth rate, and choline to support fetal nervous system development.
  

  Vitex agnus-castus contains diterpene compounds and flavonoids that exert dopaminergic action, reduce prolactin levels and increase endogenous progesterone.
  

  Each 276 gram bottle contains a 30-day supply in a peach and mango flavored powder for better compliance and ease of use.
  

  Vegan and free from GMOs, gluten, soy and dairy.

Infertility is a growing health concern for Canadians, with up to 1 in 6 couples currently experiencing difficulty conceiving. Of course, infertility can occur as a result of male or female health issues, or a combination of problems with both partners. While there may be several underlying causes or complicating factors, in women, the cause is often related to egg production, egg quality, menstrual irregularities, or hormonal imbalances. Cycle Matrix - Ovulatory & Oocyte Support - by Cyto-Matrix combines a selection of natural health ingredients to target and improve these parameters in women experiencing infertility.

A clinical presentation that often leads to infertility in women is polycystic ovary syndrome (PCOS). Physiologically, women with PCOS experience insulin resistance and subsequent elevations in androgens and suboptimal progesterone during the luteal phase of the menstrual cycle. This often results in irregular periods, poor egg maturation, anovulation, and infertility. Fortunately, dietary modifications, lifestyle changes, and several nutritional supplements have been shown to improve this dysfunctional pattern. Inositol is a prime example of a well-studied nutrient for the benefit of PCOS.

Inositol is a naturally occurring isomer of glucose and an important nutrient in the B vitamin family. It is a key component of the cell membrane and increases the sensitivity of cell receptors to serotonin, acetylcholine, norepinephrine, thyroid hormones, and insulin. At doses of 1 to 4 grams/day, inositol has been shown to improve insulin and glucose control, regulate ovulation, improve egg quality, reduce androgens, and improve fertility in women with PCOS. When combined with folic acid, inositol has been shown to improve in vitro fertilization (IVF) rates. Additionally, one study found that this same nutrient combination was more effective at inducing ovulation and achieving pregnancy in infertile women with PCOS when directly compared to metformin.

Regarding folate, although it is classically known for its importance during the first trimester of pregnancy to prevent neural tube defects such as spina bifida and anencephaly, research has shown that it also plays a crucial role in fertility and pregnancy preparation. For example, studies have shown that higher folate levels are associated with improved oocyte development, embryo quality and implantation, clinical pregnancy, and live birth rates. Furthermore, research has shown that lower folate levels may be accompanied by a higher risk of early miscarriage. The high prevalence of genetic alterations in the 5-MTHFR gene strongly suggests that 5-methyltetrahydrofolate (5-MTHF), as opposed to synthetic folic acid, is the necessary form of supplementation in all women to ensure proper absorption and utilization.

N-acetylcysteine ​​(NAC) is another promising treatment for PCOS and infertility. NAC is the rate-limiting substrate required for the production of endogenous glutathione, one of the most powerful antioxidant and detoxifying compounds in our bodies. NAC has been widely used in clinical trials to promote optimal health, particularly in cases of liver protection and respiratory disorders. In the context of women's health, NAC has been shown to improve insulin sensitivity, restore ovulation, and improve egg quality in PCOS, while significantly increasing live birth rates in women with unexplained recurrent pregnancy loss. Finally, NAC has been shown to improve pregnancy rates when used alongside clomiphene citrate in intrauterine insemination (IUI) cycles in women with unexplained infertility. Mitochondrial dysfunction, resulting from several environmental toxins, disease states, or aging, is another identified mechanism behind female infertility. This may explain why coenzyme Q10 (CoQ10), a nutrient known to support mitochondrial function and increase ATP energy production, has shown such promise in various cases of female infertility. Although CoQ10 has traditionally been used as a cardiovascular nutrient, recent research has shown that CoQ10 improves conception rates by promoting egg quality, embryo implantation, and embryonic growth. Pyrroloquinoline quinone (PQQ) is a unique antioxidant that has synergistic beneficial effects on mitochondrial function when used with CoQ10.

In some cases of infertility, the health of the endometrial lining may be a contributing concern, and L-arginine may be helpful. L-arginine has been supplemented primarily for its ability to upregulate nitric oxide and improve blood flow, explaining its benefits on intermittent claudication and physical performance, but it has also demonstrated value in women's health. Increased nitric oxide promotes blood flow to the pelvic organs, supporting endometrial receptivity, endometrial thickness, and follicular growth. One particular study found that L-arginine improved endometrial thickness and pregnancy rates in women with thin endometrial linings.

Finally, some cases of infertility may be linked to low progesterone levels, independent of PCOS. Vitex agnus-castus, commonly known as Chastetree, has long been used to increase progesterone levels and address women's health concerns. The diterpene compounds and flavonoids in vitex have been shown to exhibit dopaminergic action, thereby reducing prolactin levels and increasing endogenous progesterone. Together, these actions would explain why clinical research has shown that vitex can improve menstrual cycle regularity and PMS symptoms. In theory, improved hormonal balance may have positive effects on female infertility.

Cycle Matrix - Ovulatory and Oocyte Support combines all of these evidence-based nutrients to support women's fertility, including ovulation, egg quality, embryonic development, and successful gestation. Plus, supplemental choline to positively influence fetal brain and spinal cord formation. Fertility Matrix - Ovulatory and Oocyte Support comes in a convenient peach and mango-flavored powder for improved compliance and ease of use. Each 276-gram bottle contains a 30-day supply. Fertility Matrix - Ovulatory and Oocyte Support is vegan and free of GMOs, gluten, soy, and dairy.