DIM-Evail

• Highly bioavailable diindolylmethane.

Plant indoles, also called glucosinolates and primarily found in cruciferous vegetables, offer multiple benefits to human health. These vegetables are well known for their impact on reducing the risk of cancer and many chronic diseases. Two of the main indoles derived from cruciferous vegetables are I3C (Indole-3-Carbinol) and DIM (Diindolylmethane). Therefore, DIM is not naturally present in these vegetables since it is released following an enzymatic process during the grinding of broccoli, cauliflower, cabbage, or Brussels sprouts or during human digestion. Stomach acid, or HCl, can also promote the coupling of two indole-3-carbinol molecules to form diindolylmethane. A lack of HCl will therefore hinder an individual's ability to produce DIM from I3C2.

Essentially, DIM consists of two I3C molecules combined. However, encapsulated I3C does not store well because it is sensitive to light, heat, and moisture. Additionally, it is a stomach irritant, and research indicates possible side effects at doses above 300 mg per day, such as dizziness and unsteady gait, potentially caused by nervous system toxicity. One study shows that 90% of orally consumed I3C converts to other compounds, which may be responsible for these side effects. ICZ, or indolocarbazole, is one such compound known to cause DNA damage. Studies on DIM show no toxicity when administered at three times the human dose.

Due to its crystalline structure, DIM absorption is minimal when administered orally. For this reason, DIM-Evail is manufactured using Designs for Health's all-natural Evail formulation, which has been shown to enhance DIM absorption. A blend of MCT oil, non-soy lecithin, and vitamin E are used without the use of potentially harmful surfactants.