Seulement 1 item(s) en stock!
This product is available from the supplier. Order today and receive your order in 24-72 hours.
Vitamin B9, known as folic acid or folate, cannot be synthesized by the body, so we rely on our diet. Folate is found primarily in green leafy vegetables, legumes, eggs, beans, and citrus fruits. It is physiologically necessary for the proper synthesis of DNA and RNA, red blood cell production, protein metabolism, energy production, and even neurotransmitter synthesis. Unfortunately, lifestyle habits, dietary choices, certain medications, and illnesses can all deplete the body's folate stores.
The need for folic acid supplementation became evident decades ago when it was identified that pregnant women who lacked sufficient levels were at greater risk of giving birth to children with birth defects. Following this discovery, many foods are now fortified with this crucial nutrient.
The challenge is that folate exists in several forms, and not all individuals have the enzymatic capacity to convert them to the most active form, known as 5-methyltetrahydrofolate (5-MTHF). Folic acid is the synthetic form of folate, which requires several enzymes and steps to ultimately reach the bioactive form of 5-MTHF. A key enzyme, 5-MTHF reductase, has been identified as problematic in a significant proportion of the population.
Research has revealed that a significant percentage of the population has a suboptimal ability to convert folic acid to 5-MTHF due to a genetic variation. Up to 20% of people of European descent have two copies of this genetic mutation, while 40% to 50% of the same population have one copy. With two copies, the body's ability to convert folate to 5-MTHF is reduced by 60%, and studies have shown that people with two copies of the variant are at greater risk for certain diseases. Those with only one copy of the gene variant have their conversion capacity reduced by 35%. The high prevalence of these genetic changes suggests that 5-MTHF is the necessary form of supplementation in all individuals to ensure that even those with a 5-MTHF reductase mutation can still fully absorb and utilize folate.
Folate is particularly important during the first trimester of pregnancy to fuel the rapid growth of the developing brain and nervous system. Specifically, low levels have been linked to neural tube defects such as spina bifida and anencephaly, as well as a higher risk of early miscarriage. Folate deficiency is also classically known to cause macrocytic anemia, but fewer people realize that it can contribute to cardiovascular disease, stroke, and even mental health imbalances.
Low levels of 5-MTHF in the blood have long been found in populations of low-mood individuals. Studies have since confirmed that 5-MTHF is a viable and extremely safe treatment option as a stand-alone therapy, as well as in combination with SSRI antidepressants. In fact, for individuals who respond poorly to SSRI antidepressants, 5-MTHF is particularly indicated and has been shown to increase the effectiveness of the medication. Overall, folate is imperative when it comes to mood regulation. Cyto-Folate offers the highly bioavailable form of 5-MTHF to ensure proper utilization in the body, regardless of genetic profile.
Cyto-Folate combines 200 mcg of 5-MTHF with 20 mcg of active methylcobalamin per drop, allowing for variable and targeted dosing. Methylcobalamin is added to ensure that folate supplementation does not mask B12 deficiency, a phenomenon that can occur when folate is given alone. Each bottle of Cyto-Folate is lightly sweetened with a natural blueberry flavor.
Thanks for subscribing!
This email has been registered!
