CortAlign contains a unique variety of herbs and nutrients that have been shown to moderate stress and anxiety and normalize cortisol secretion. Ashwagandha has several adaptogenic effects, including modulation of GABA receptors, which is partly responsible for the significant reduction in anxiety and stress demonstrated in clinical trials. The KSM-66TM formulation of ashwagandha, in particular, has been shown to reduce serum cortisol levels by 27% and improve markers of depression, stress, and anxiety compared to a placebo.
The combination of magnolia and phellodendron (Relora®blend) helps reduce stress and anxiety and has been shown to reduce salivary cortisol levels and stress perception, improve other mood parameters, and prevent stress-related weight gain compared to placebo. Phosphatidylserine plays a critical role in neuronal cell structure and function and has been shown to dampen the stress response, improve mood, and normalize cortisol release.