CoQmax Ubiquinol

• Provides antioxidants.

CoQ10 and the CoQ10 cycle play a fundamental role in the body's antioxidant and energy systems. The ubiquinone form of CoQ10 is produced in the mitochondria, where it participates directly in energy production by accepting electrons into the electron transport chain. Through the action of an oxidoreductase enzyme, ubiquinone is rapidly converted to ubiquinol, the fat-soluble form that supports antioxidant activity throughout the body. The conversion of ubiquinone to ubiquinol declines with age, particularly after age 40. Supplementation can help maintain normal levels of ubiquinol in the body as well as prevent drug-induced nutrient depletion of CoQ10. Until recently, the ubiquinol form was not effective as a supplement because it was chemically unstable and easily oxidized. CoQmax UbiquinolTM contains a patented, absorbable form of ubiquinol that maintains its structure and stability in the gastrointestinal environment.

Antioxidant Status Oxidative stress is detrimental to the integrity and function of cell membranes and tissues, and ultimately to DNA itself. Antioxidant status must be maintained throughout the body to protect vulnerable cells. Research indicates that ubiquinol supports antioxidant activity, including the regeneration of vitamins C and E, helping to maintain normal levels of free radical activity in the body. Researchers also suggest a possible role for CoQ10 in redox control of cell signaling and gene expression.

Antioxidant protection is vital for maintaining the integrity of cholesterol and its role as a precursor to vitamin D, hormones, cell membranes, and brain tissue. Reactive oxygen species, including superoxide released by immune cells, cause cholesterol oxidation and can transform a vital biochemical precursor into a toxin.

Serum CoQ10 levels decline with age, but also decrease with inhibition of the enzyme HMG-CoA reductase, an enzyme essential for CoQ10 production. In cases of reduced production or drug-induced nutrient depletion, physicians recommend CoQ10 supplementation to help maintain normal levels in the body. The related depletion of vitamin E in lymphocytes may raise further concerns about patients' vulnerability to oxidative stress.

Heart health research suggests that patients experienced significant support for heart function after receiving ubiquinol supplementation (an average of 450-580 mg per day). These patients achieved more desirable serum CoQ10 levels when they switched from ubiquinone to ubiquinol. Researchers suggest that ubiquinol significantly improved absorption. Research in older adults also suggests that supplemental CoQ10 may increase tolerance to aerobic stress in cardiac tissue.

The role of CoQ10 in aging has become a topic of great interest. Supplementation with both forms of CoQ10, ubiquinone and ubiquinol, was studied in a SAMP1 mouse model. The results suggest that the ubiquinol form more effectively increased CoQ10 levels in the liver (the main target tissue), followed by the kidneys, heart, and brain. Ubiquinol also appears to have a more positive effect on maintaining healthy function than ubiquinone.

Kaneka QHTM Stabilized Ubiquinol was developed by Kaneka Corporation (the world's largest manufacturer of CoQ10) and has been shown to be safe and bioavailable after single and multiple doses.