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Iron continues to be the most common nutrient deficiency in the developed world, with a particularly high prevalence among women and during pregnancy. In fact, 1 in 2 women will be iron deficient at some point in their lives, and even more will suffer from symptoms associated with suboptimal iron levels. While fatigue, weakness, hair loss, and pallor are classic symptoms of iron deficiency anemia, low iron levels affect many other body systems.
For example, iron deficiency has been shown to be a common cause of agitated syndrome in about 1 in 4 cases, and iron supplementation can improve symptoms. This is thought to be achieved by iron's upregulation of dopamine synthesis from tyrosine. It is also well documented that children and adults perform worse on tests of mental function in iron-deficient states, with areas such as attention, memory, and concentration being affected.
Iron also plays a critical role in many hormonal pathways. Iron is required for thyroid conversion of thyroxine (T4) to triiodothyronine (T3), and in hypothyroidism with concomitant iron deficiency, combined treatment with iron and levothyroxine has been shown to be superior to either treatment alone. In women with heavy menstrual bleeding, iron deficiency can cause recurrent heavy menstrual bleeding by weakening the uterine muscles, thereby worsening the condition. Evidence also shows that women with unexplained infertility and suboptimal iron status may benefit from iron replacement therapy.
Finally, iron is necessary for proper immune function through the production of cytokines in macrophages, and iron deficiency can lead to an inadequate immune response. For example, research in people with oral thrush has shown that iron restoration can reduce the number of salivary thrush infections and reduce oral lesions.
Despite all the health benefits of targeted iron supplementation, many women and iron-deficient individuals are reluctant to take iron supplements or become noncompliant due to digestive side effects such as constipation, nausea, and stomach upset.
Cyto-Matrix's Bio-Ferra is a highly bioavailable liquid iron supplement containing an iron polysaccharide complex (PIC). PIC is unique in that it is non-ionic, does not require vitamin C for absorption, and is extremely safe with an LD50 (lethal dose 50) of 5,000 mg/kg, compared to the toxicity potential of iron salts with an LD50 of only 230 mg/kg. Each teaspoon of Bio-Ferra provides 20 mg of elemental iron in a natural green apple flavor and is suitable for vegans and vegetarians.
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