Ashwagandha (Withania somnifera) has long been used as a key adaptogen in Ayurvedic medicine. It is credited with numerous benefits, including increased resistance to stress and anxiety, improved physical performance and immune function, and improved fertility, sleep, and neurological function. Its diverse phytochemistry includes withanolides, sitoindosides, phenolic compounds, and flavonoids, which help explain its diverse physiological actions, ranging from cardio- and neuroprotective to anti-inflammatory and anxiolytic effects.
KSM-66 is a full-spectrum ashwagandha extract using only the roots of the plant, notable for the large number of randomized, controlled trials documenting its effectiveness. Clinical trials have demonstrated significant improvements in symptoms and cortisol levels in participants with chronic stress, as well as improved weight control and food cravings in this population. It has also been shown to improve overall well-being, sleep quality, and mental alertness in older adults, as well as memory and executive function in those with cognitive impairment. Clinical trials document increased cardiorespiratory endurance, as measured by VO2 max, in male and female athletes using KSM-66, as well as greater increases in muscle mass and strength when combined with resistance training. Additionally, KSM-66 extract has demonstrated benefits in improving sleep quality, enhancing sexual function in both men and women, restoring spermatogenic activity in oligospermic men, and improving thyroid function in individuals with subclinical hypothyroidism.